If you are a scientist willing and able to perform experiments on a gene, you are eligible to register as a "Scientist User" in ModelMatcher. Please register through the Scientist Registry page and confirm your email account to continue. Once you are logged in, you will be prompted to enter some basic information about yourself including your name, affiliation and position under the -Profile- tab. You will be asked to provide information on what type of research you do, and what organ systems you study if applicable. There is also a section where you can briefly describe your research and use PubMed IDs (PMIDs) to link to relevant publications. Once you have completed this, please save the information and you can then start to enter your genes of interest.
Navigate to the -Model Organisms- tab at the top of the profile page in order to register your specific genes of interest. If you do not work in a model organism supported by ModelMatcher, please enter the information under the "Human/other" entry using human gene nomenclature that is orthologous to your gene of interest. Begin typing the model organism gene name according to the official nomenclature in the bar and select the correct gene as it appears in the autofill. You can list as many genes of interest as you like for each model organism. You can also select whether a gene is "Primary or Secondary", and if you would like a "Restricted or Public" privacy setting for a specific gene. Please see the glossary below to learn more about these terms. Save your selections and your registration with ModelMatcher is complete. You can always add or remove genes according to your interest by logging into the Scientist Registry.
After you register your gene of interest, you may receive messages from our Match Dashboard or partner registry users who want to discuss a collaboration with you. These will come as official emails from email@example.com and will include information about the user and the gene they are interested in. Here is an example of one such email. Alternatively, for genes that you registered as Public, you may receive direct emails from potential collaborators. If you wish to discuss a collaboration with them, you should simply reach out to the other party through their preferred email address, which will be clearly displayed in the Match Request email. Please note that you can receive a Match Request for genes you have registered as Restricted. In this case, the message was sent to you anonymously without revealing your name or information to the requesting user. If you are not interested in this specific request and wish to remain anonymous, simply do not respond to the request.
If you are a scientist registered with ModelMatcher, but also want to find other scientists with similar interest or complementary skills to collaborate with, you can do so by using the Search feature or by creating a Match Dashboard account. This will allow you to connect with other scientists who share a gene of interest. A different email and a password can be used to register in the Scientist Registry and Match Dashboard but we recommend to keep this the same to avoid any confusion.
Anyone can register to be a Match Dashboard User. Please register here and confirm your email account to continue. Once you are logged in, you will be prompted to enter some basic information about yourself including your name, what type of Match Dashboard User you are, a preferred email address (optional), and a brief statement regarding why you are joining ModelMatcher under the -Profile- tab. Once you have completed this, save this information and you can then start to list your genes of interest.
Navigate to the -Match with Scientists- or -Match with Clinicians and Patients- page to list your genes of interest. Begin typing the current NCBI human gene symbol and select the gene as it appears in the autofill section. You can list as many genes of interest as you like. Once you have entered your genes of interest, save your selections. A table will appear that lists your genes of interest.
Your -Match with Scientists- tab now has a table showing Scientists who have registered the same human gene of interest, or one of its predicted homologs in model organisms.
Your -Match with Clinicians and Patients- tab allows you to identify clinicians and patients registered in Matchmaker Exchange who share common genes of interest. To send match requests, click the Exchange info button next to the gene, input your reason for contact, select the partner registries you want to match with, and hit the send button. This will send the match request information to our partner registries and will notify you if there are matches within those networks.
Navigate to our public search page and input a gene of interest. You can narrow results by selecting the tier, animal model, or organ system you are interested in. The system will display the predicted homologs of your gene of interest, and a table displaying all of our registered scientists who have expressed interest in that gene. You can navigate to their profile pages to learn more about their research and collect contact information. Some users will be listed as anonymous and will require you to register a Match Dashboard account to contact them. Anyone is allowed to make one of these accounts. It is completely free and there are no required qualifications, just an email address verification step.
Scientists: Users who are scientists with expertise in specific genes who access ModelMatcher. Scientists who register in ModelMatcher are willing to use in vivo, in vitro, and/or in silico methods to experimentally study the function of genes and variants linked to human diseases.
Non-Scientist Users: Users with a clinical interest who access ModelMatcher to identify scientific collaborators. These users may be clinicians (e.g. physicians, genetic counselors) who are trying to diagnose a rare disease patient, patients themselves, or their family members who wish to participate in research to understand the mechanism of their disease. Funding agencies and non-profit organizations can use ModelMatcher as non-Scientist Users to identify a group of scientists with expertise in a specific gene to facilitate collaborative research.
Genes of expertise/interest: A list of genes that a Scientist User registers in ModelMatcher as having expertise or interest in.
Public genes: A subset of genes of expertise/interest that can be discovered by non-Scientist Users using the “Search” feature, which does not require the user to be logged in or registered with ModelMatcher. These typically include genes in which the Scientist User has published on the past and considers non-confidential.
Restricted genes: A subset of genes of expertise/interest that can only be discovered by Match Dashboard Users using the "Match Request" feature, which requires the user to register with ModelMatcher or other federated matchmaking databases. These typically include genes in which the Scientist User has unpublished data on and considers confidential.
Primary genes (tier 1 genes, genes Scientist Users currently work on): : These are genes which Scientist Users' labs actively work on, and have reagents and protocols ready to perform functional assays.
Secondary genes (tier 2 genes, genes Scientist Users currently don't work on): These are genes which Scientist Users' labs have worked on in the past or have strong interest in, but would need additional time to establish protocols or create reagents to perform functional assays.
Match Dashboard: A personalized page for users to register their genes of interest to identify potential collaborators in ModelMatcher and our partner registries. Users can reach out to scientists, clinicians, and patients by submitting "Match Requests". This is the only way a user can reach out to Scientists who registered their genes of interest as "Restricted".